number of units of TOUJEO to be injected and no conversion is required. Unlike most other insulins, Toujeo has no pronounced peak and it doesnt wear off between doses. 1:1 CONVERSION. • During changes to a patient’s insulin regimen, increase the frequency of blood glucose monitoring [see Warnings and Precautions (5.2)]. It is also used to tr To minimize the risk of hypoglycemia, do not administer TOUJEO intravenously, intramuscularly or in an insulin pump. Better absorption with smaller doses seems like a relative concept with basal and maybe is more meaningful with bolus-- where the speed of absorbtion is measured over a couple hours vs many? Obesity adds to inherent insulin resistance in T2DM and may be an independent cause of insulin resistance in T1DM. In reality, some dose adjustments can be expected (according to clinical trial data), but it isn’t a matter of converting to a three times smaller dose. The U stands for units. After all, both Lantus and Toujeo contain the same insulin , called insulin glargine. Believe it or not though, that isn’t the case. A reduction in the Lantus® dose may be re Changes in insulin strength, manufacturer, type, or method of administration may result in the need for a change in insulin dose or an adjustment in concomitant oral antidiabetic treatment. The 20% reduction was what we were taught in therapeutics, but the sanofi website here claims a 1:1 conversion from other basal insulins. The health information contained herein is provided for general educational purposes only. The biggest difference between the two basal insulins is that while Lantus contains 100 units/mL, Toujeo is more concentrated and triples Lantus' capacity, yielding 300 units/mL. I also had it in my head that there was a U-60 at one time, but I may be wrong about that, as a quick Google search only turns up articles about the German Sub U-60, which apparently had one of the least distinctive war records of the Nazi fleet -- and no discussions of insulin. Référence : Monographie de TOUJEO ® SoloSTAR et TOUJEO ® DoubleSTAR, sanofi-aventis Canada inc., 12 mai 2020. However, a warning: It’s impossible to give a concentrated answer about concentrated insulin! Anyway, back in the many-conce A subreddit for pharmacists, pharmacy students, techs, and anyone else in the pharmaceutical industry. One milliliter of Toujeo contains three times as much insulin as Lantus. is 80% of the Toujeo dose. Hypoglycemia is the most common adverse reaction of insulin therapy, including Lantus®, and may be life-threatening. Email us at [email protected]} Matthew, type 2 from Oregon, asks: I’m confused about the new basal insulin Toujeo, I understand that it is U-300 and therefore should be more “concentrated,” but when I went to the webpage for this product, it talked about how Toujeo is a 1:1 dosing and conversion from Lantus. Warnings and Precautions Toujeo® contains the same active ingredient, insulin glargine, as Lantus®. U-100 is also referred to as regular insulin, but this can be confusing since many different types of insulin come in this concentration. It is recommended for patients requiring at least 20 units per day. TOUJEO Max SoloStar contains 900 units of TOUJEO U-300. e.g. because yes, even though toujeo is less effective when compared 1:1 to lantus, cutting insulin dose by 80% is a lot different than cutting by 20% (lowering to 80% is what you meant i hope). While Lantus is suitable for people with diabetes who are age 6 and up, Toujeo is only approved to treat patients who are 18 years and older. The U100 basal insulins include neutral protamine Hagedorn (NPH), glargine, degludec, and detemir, as well as short-acting human regular insulin and short-acting insulin analogs (such as lispro, aspart, and glulisine). Glargine (the insulin in both Lantus and Toujeo) is an insulin analoguemeaning it has been modified from regular insulin to change its structure and the way it is absorbed. In controlled clinical studies comparing LANTUS to NPH insulin, 593 of 3890 patients (15%) with type 1 and type 2 diabetes were ≥65 years of age and 80 (2%) patients were ≥75 years of age. Toujeo. Toujeo peut réduire le risque de baisse de la glycémie, ce qui peut être un effet secondaire grave. Please see additional Important Safety Information for Toujeo on next page. 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As a general rule OHAs (Oral hypoglycemic agents) are prescribed for Type 2 diabetes. Basaglar. Lantus is the world’s most prescribed insulin. Toujeo is more concentrated than Lantus and absorbs slower. • Inject TOUJEO subcutaneously once a day at the same time of day. When changing from another basal insulin to Toujeo®, patients experienced higher average fasting plasma glucose levels in the first few weeks of therapy until titrated to their individualized fasting plasma glucose targets. The average retail price for 3 prefilled 1.5 mL pens of 300 units of insulin per mL of Toujeo (the most frequently filled prescription according to GoodRx data) is about $477. It does take several hours to take effect, however. Toujeo is used to lower blood glucose and improve diabetes control in adults with type 1 or 2 diabetes mellitus. This week, the drug manufacturer announced the FDA has approved Toujeo, its new once-daily long-acting basal insulin. because on a unit vs unit basis, according to uptodate, toujeo is less effective than lantus at lowering blood glucose. This means that if you are injecting 50 units of Lantus, you can essentially be switched over to Toujeo and instructed to inject the exact same amount, 50 units. The most commonly prescribed insulins are referred to as “U100” insulin in which 100 units of insulin are suspended or dissolved in 1 mL of liquid. 1u of toujeo = 1 u of lantus in terms of how much medication it is, it is just a different amount of liquid volume. Discutez avec votre médecin si vous souhaitez changer d'insuline. Lantus et Toujeo sont deux insulines à action prolongée utilisées pour traiter le diabète. After all, both Lantus and Toujeo contain the same insulin , called insulin glargine. Analysts noted, however, that lower rates of hypoglycemia seen in clinical trials comparing Toujeo to Lantus, were not mentioned on the FDA-approved label. User flair is enabled for all users to edit themselves! Conversions for inhaled insulin are discussed here - inhaled insulin dosing; Lantus, Semglee, Basaglar, Levemir, and Tresiba . Does anyone know why this is? Limitations of Use: Lantus® is not recommended for the treatment of diabetic ketoacidosis. Continue reading >>, Early in 2015 the FDA approved the first concentrated long-acting insulin known as Toujeo (insulin glargine), and it’s now available in pharmacies. is the same as the Lantus dose. Continue reading >>, Brand Name: Toujeo Generic Name: insulin glargine injection, U-300 Medication Class: Long-acting insulin Similar Drugs: insulin glargine (Lantus), insulin detemir (Levemir) Manufacturer: Sanofi-Aventis US FDA Approval date: February 2015 What is Toujeo and its mechanism of action? Toujeo package insert says when switching from Lantas to Toujeo that more units may be required. 2 Insulin glargine (Lantus) to insulin detemir (Levemir) • Convert unit-per-unit. In addition to gaining patients through conversions, there are about a million new patients for basal insulin each and every year. *This offer is not valid for prescriptions covered by or submitted for reimbursement under Medicare, Medicaid, VA, DOD, TRICARE, or similar federal or state programs, including any state pharmaceutical programs. I see a lot of confusion around the different dosages, and a few common questions: Is it normal for my dose of Toujeo to be more than my Lantus dose? Can Metformin Be Used To Prevent Miscarriage? Fast forward a decade and a half later, and insulin glargine (originally Lantus) has reinvented itself. Both Lantus and Toujeo contain insulin glargine. Continue reading >>, 100 units/mL (Lantus SoloSTAR; Basaglar KwikPen; 3 mL disposable prefilled pens) 300 units/mL (Toujeo; 1.5 mL SoloStar disposable prefilled pen) 300 units/mL (Toujeo Max; 3 mL SoloStar disposable prefilled pen) Note: Recent studies have suggested that glargine-300 extends blood glucose control well beyond 24 hr Long-acting basal insulin indicated to improve glycemic control in adults with type 1 diabetes mellitus Start ~1/3 of total daily insulin dose; use remaining 2/3 of daily insulin dose on short-acting, premeal insulin Usual initial dose range: 0.2-0.4 units/kg; optimal glucose lowering effect may take 5 days to fully manifest and the first insulin glargine dose may be insufficient to cover metabolic needs in the first 24 hr of use Titrate insulin glargine per instructions, and adjust coadministered glucose-lowering therapies per standard of care See Dosing Considerations and Administration Long-acting basal insulin indicated to improve glycemic control in adults with type 2 diabetes mellitus Start 0.2 units/kg qDay; if necessary, adjust dosage of other antidiabetic drugs when starting insulin glargine to minimize the risk of hypoglycemia See Dosing Considerations and Administration Dose must be individualized based on clinical response; blood glucose monitoring is essential in all patients receiving insulin therapy Patients adjusting the amount or timing of dosage should do so only under medical supervision with appropriate glucose monitoring Titrate Toujeo dose no more frequently than every 3-4 days Use with caution in patients with visual impairment who may rely on audible clicks to dial their dose If changing from a treatment regimen with an intermediate- or long-acting insulin to a regimen with insulin glargine, the amount and timing of shorter-acting insulin It lowers blood glucose by stimulating glucose uptake by skeletal muscle and adipose (fat) tissue, and also reduces glucose production in the liver. I love Toujeo, no more split doses, no late night is known that smaller volumes of injections absorb better, that would on average suggest that with Toujeo you might need less of a dose. Units are standardized. To minimize the risk of hypoglycemia, do not dilute or mix TOUJEO with any other insulin products or solutions. Or does anyone have experience switching between products that can vouch for needing the dose change? Whether the ratio is expressed somewhere in the literature to an actual average variability I am not sure... but at least that is some reference to a unit per unit that more Toujeo may be needed than Lantus. Your healthcare professional is the single best source of information regarding your health. Toujeo has the same active ingredient as Lantus, called insulin glargine, but at three times the concentration and with a design to release the insulin more gradually. At the end of the trial, the reducti Continue reading >>, Toujeo® is a long-acting human insulin analog indicated to improve glycemic control in adults with diabetes mellitus. According to the manufacturer, Sanofi-Aventis, a higher dose can be expected with Toujeo and is completely normal. (Find the full prescribing info for Toujeo at the bottom of this article.)…. Its also important to note that it can take five to eight days of daily dosing to reach a functional concentration in the body, according to Healthline . Don't worry, Wil's got this... {Have your own questions? Monitor blood glucose in all patients treated with insulin. How effective is Toujeo? Insulin glargine was introduced in the year 2000. The remainder of the total daily insulin dose should be given as a short-acting insulin and divided between each daily meal.
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