Additionally, women with uVIN and no SCC areas had a still lower median age at the time of diagnosis: 36 years (SD 10.8 years). Chiudendo questo banner, scorrendo questa pagina o cliccando qualunque suo elemento acconsenti all’uso dei cookie. The role of p16INK4a expression in uterine cervical cancer is well established. HPV16 was the predominant genotype, followed by HPV18 and HPV33. Adi Shakti - Bhakti Mantra - Duration: 12:43. Od 1990. je radila kao manekenka prije nego što je pažnju svjetske javnosti privukla u filmu Il Postino (Poštar), tumačeći ulogu lokalne ljepotice u koju se zaljubi glavni junak.. Izvori Adnexal masses are not common in pregnancy. Guarda il profilo completo su LinkedIn e scopri i collegamenti di Maria Grazia e le offerte di lavoro presso aziende simili. Baidu: Search more result on Baidu about Barcellona Dr. maria Grazia Medico Chirurgo, Palermo, Italia Bing: Search more result on Bing about Barcellona Dr. maria Grazia Medico Chirurgo, Palermo, Italia Google: Search more result on Google about Barcellona Dr. maria Grazia Medico Chirurgo, Palermo, Italia Yahoo: Search on Yahoo Barcellona Dr. maria Grazia Medico Chirurgo Contatti. Login failed. Join Facebook to connect with Maria Grazia Piccioni and others you may know. This site uses cookies. Oggetto. Sono nata a Roma il 17 Dicembre del 1957 e nella mia città natale ho posto in essere i miei studi universitari. Contatti; Categorie attivita. Svolge il suo lavoro con piena dedizione e passione, e' interessata ad una paziente e veramente vuole aiutarle. HPV DNA was identified in 16/92 samples (17.4%), while diffuse positivity for p16 and p53 was observed in 100% and 6.2% of HPV-positive tumors and in 2.3% and 64.5% of HPV-negative tumors, respectively. Five hundred and eighty-seven of the total 2,296 (25.5%) evaluated cases proved to be VIN and 1,709 (74.4%) were identified as IVC. Patient age was unremarkable, with some exceptions: the mean age of women with HPV16 positivity (and the relative E6/E7 transcription) was significantly lower (p<0.001) than that of women with vulvar cancers not linked to HPV DNA. Directions: Search the directions to Sinatra Dr. maria Grazia, Milano, Italia Google Maps Address: Search on Google Maps with the address Sinatra Dr. maria Grazia, Milano, Italia Google Maps GPS: Search on Google Maps with the GPS Sinatra Dr. maria Grazia, Milano, Italia Hotels: Search a Hotel in Milano, Italia Hostels: Search a Hostel in Milano, Italia Scegli la consulenza online per iniziare o continuare una terapia, senza muoverti da casa. I magnetici anni 17,307 views. Mariagrazia Piccioni is on Facebook. If you have access to a journal via a society or association membership, please browse to your society journal, select an article to view, and follow the instructions in this box. High morbidity and recurrence rates after surgery make less invasive treatments highly advisable. The references of the included studies were independently hand-searched to identify other potentially relevant studies and to eliminate duplicates. LEARN MORE. Margaret and Lino Piccioni Email: linomargaret@gmail.com Tel. Se vuoi seguire in tempo reale la mia attività basta mettere mi piace alla mia pagina Facebook e Instagram @Maria grazia Carbonari. Further, larger and controlled studies are needed to obtain consensus diagnostic results in order to use these markers in everyday clinical practice as a valid, effective and economically convenient instrument. A comparable trend was found for p16INK4a, thus showing a high correlation between the 2 markers. … Maria Grazia Piccioni . Facebook gives people the power to share … Maria Di Grazia. a case-control study: GYNECOLOGICAL ENDOCRINOLOGY: 2020: Infatti, si è scoperto che molti dei volatili vengono drogati con cocaina o antidolorifici. Join Facebook to connect with Grazia Piccioni and others you may know. For HPV-related basaloid/warty VSCC, p16INK4 immunostaining was able to distinguish transforming HPV infections better than HPV DNA detection and with higher interobserver agreement. Visualizza il profilo di Maria Grazia Picchioni su LinkedIn, la più grande comunità professionale al mondo. p53 positivity was, by constrast, of high intensity in HPV-negative tumors, dVIN and squamous cell hyperplasia. Join Facebook to connect with Maria Grazia Piccioni and others you may know. Facebook gives people the power to share and makes the world more open and connected. Two independent reviewers evaluated all studies to verify the inclusion criteria and make sure the PRISMA guidelines were followed while elaborating this review. The primary aim was the detection of the immunohistochemical pattern of expression of the 2 types of vulvar cancers and its accuracy: warty/basaloid (HPV-related) and differentiated keratinizing (HPV-independent). For more information view the SAGE Journals Article Sharing page. In specimens of keratinizing VSCC, HPV positivity ranged from 1.3 to 13.3% and p53 immunostaining was positive in 64.5% of cases where evaluated. m-e-r-a-v-i-g-l-i-o-s-a! The evaluated studies showed comparable p16INK4a immunoreactivity and HPV positivity in HPV-related uVIN. Please check you selected the correct society from the list and entered the user name and password you use to log in to your society website. Also, Ki67 immunostaining showed high, diffuse and nuclear positivity in uVIN, while it was absent or confined to the parabasal epithelial layer in dVIN and it was absent in normal epithelium. Yelp is a fun and easy way to find, recommend and talk about what’s great and not so great in Catania and beyond. Indirizzo PEC: mariagraziapicciano@ordineavvocatiroma.org Categorie: Avvocati. Scopri quali alberi ha e tutto quello che sta facendo per rendere il mondo più verde. However, combined modalities with topical treatment (imiquimod or cidofovir) and a surgical approach may represent the best treatment for this multiform disease (13, 19, 20, 22–23–24). In specimens of warty/basaloid VSCC, HPV positivity ranged from 62.5% to 100%, p16INK4a immunoreactivity from 76.4% to 100%, and p53 immunostaining was positive in 6.2% of cases. The email address and/or password entered does not match our records, please check and try again. Responsive Design. the site you are agreeing to our use of cookies. Maria Grazia Porpora Purpose: To compare sonohysterosalpingography (sono-HSG) with foam instillation (HyFoSy) versus saline solution (HyCoSy) in the evaluation of tubal patency. Therefore, the clear recognition of HPV-related lesions should lead to an appropriate strategy of treatment and follow-up. The positivity criteria for p16INK4a immunostaining were highly homogeneous in all studies: strong nuclear and cytoplasmic staining in the basal and higher layers of epithelium was considered positive for p16INK4a expression. Nel dramma la Ginzburg disegna il ritratto di un matrimonio, di carattere piuttosto borghese, tra l'avvocato Pietro e Giuliana, una giovane donna di bassa estrazione sociale conosciuta ad una festa. Normal vulvar epithelium, nondysplastic lesions and HPV-related uVIN and basaloid/warty VSCC were negative for p53, while nuclear and diffuse p53 immunostaining was detected in dVIN and keratinizing VSCC. View or download all the content the society has access to. By continuing to browse Aggiungi una recensione Fai … Maria Grazia Porpora 1 , Roberto Brunelli, Graziella Costa, Ludovica Imperiale, Ewa K Krasnowska, Thomas Lundeberg, Italo Nofroni, Maria Grazia Piccioni, Eugenia … Maria Grazia Piccioni. All included studies allowed comparison of immunochemistry triage with HPV DNA PCR test. One-hundred and seventy-seven samples were considered: 123 cases of VIN, 41 cases of VSCC, and 13 benign squamous epithelium samples. ITALIA Via San Cornelio e Cipriano 11 20866 Carnate Milano italia Tel: (+39) 671369 Cell: (+39) 3407301596 email:info@facchinettimariagrazia.it UK Esmond Court Thackeray Street W8 5HB London uk Tel: (+44) 7760992429 email:info@facchinettimariagrazia.it A systematic literature search was conducted to target all scientific publications related to the evaluation of p16INK4a immunoreactivity versus HPV testing and p53 immunoreactivity in vulvar diseases (VIN and VSCC) from January 2004 to December 2016. Intervista alla Dott.ssa Maria Grazia Piccioni per il programma Live Social. Dati, Piccioni-Ippoliti Maria Grazia 062315464 Via Marcio Rutilio, 41 vedi indirizzo, numero di telefono, cerca CAP, comune, mappa Piccioni-Ippoliti Maria Grazia 062315464 Via … The key search terms were HPV, VIN, p16INK4a immunochemistry and p53. The characteristics and technical information of these 8 studies are listed in Table I. Cases of invasive vulvar cancer (IVC) and vulvar intraepithelial neoplasia (VIN) have been rising recently among younger women and the rates of new vulvar cancer events have increased by 0.5% each year over the last 10 years (2, 3). Lean Library can solve it. Address Sisters By MARIA GRAZIA DONDI - Via Jacopo da Porto Sud, 509, 41126 Baggiovara (MO) Members of _ can log in with their society credentials below. p16INK4a, HPV DNA, MIB1 and p53 were examined using immunohistochemical staining, which identified nuclear positivity. HrHPV-associated premalignant lesions and carcinomas showed intense and diffuse nuclear and cytoplasmic immunostaining for p16INK4a, while no expression of p16INK4a or heterogeneous expression was found in normal vulvar epithelium and nondysplastic lesions. Therefore, the clear recognition of HPV-associated VIN would lead to an appropriate strategy of treatment and follow-up. Directions: Search the directions to Mazzari Dr. maria Grazia, Crema, Italia Google Maps Address: Search on Google Maps with the address Mazzari Dr. maria Grazia, Crema, Italia Google Maps GPS: Search on Google Maps with the GPS Mazzari Dr. maria Grazia, Crema, Italia GPS Address: Ho anche uno studio privato situato in Roma, quartiere Parioli, in viale Liegi 52. Conflict of interest: The authors declare they have no competing interests related to this article. +39 339 44 44 247 Casa Piccioni Strada Vecchia Passera-Vedasco 6 28838 Stresa Frazione Passera Italia Lavasecco Azzurra di Fassari / Maria Grazia - Laundry Services - Via dei Piccioni, 11, Catania, Italy - Phone Number - … Immunohistochemistry was performed in 3,110 specimens with a histological diagnosis of VIN and VSCC, including also 2% (n = 63) of samples of normal epithelium or nondysplastic lesions (hyperplasia, lichen sclerosus, lichen simplex chronicus, seborrheic keratosis, condylomas). Differently from dVIN, there is no agreement on the gold-standard treatment for uVIN, which often presents multicentric and multifocal involvement. Non hai trovato sul profilo dello specialista le informazioni che cercavi? 570 d. vind-ik-leuks. Lavasecco Azzurra di Fassari / Maria Grazia in Catania, reviews by real people. 460 Followers, 366 Following, 55 Posts - See Instagram photos and videos from Maria Grazia Piccinini (@mariagrazia1) Basic statistical analysis was conducted using common methods of descriptive statistics with assessment of arithmetic mean, minimum and maximum values and geometric mean to evaluate the sensitivity and specificity percentages of p16INK4a and HPV DNA, p53 and Ki67. views: 625 Maggio 22, 2019 2:23 pm. Most of them showed close areas positive for squamous cell carcinoma (SCC). Visita ginecologica + ecografia pelvica + pap-test a Roma, Malattia sessualmente trasmissibile a Roma, Ginecologi con Allianz global assistance (mondial assistance ) a Roma, Ginecologi con Unipol assicurazioni (unisalute) a Roma. Buongiorno, sono la dottoressa Maria Grazia Piccioni e vi do il benvenuto sul mio profilo. Maria Grazia Piccioni is on Facebook. www.miodottore.it © 2021 - HPV-related carcinogenesis is characterized by hrHPV DNA integration into the host DNA (10). Prenota la tua visita online! I have read and accept the terms and conditions, View permissions information for this article. In the study by Hoevenaars et al (13), VIN specimens of 120 consecutive patients were examined: 75 had dVIN and 45 had uVIN. E' una perla molto rara. Maria Grazia Porpora 1 , Roberto Brunelli, Graziella Costa, Ludovica Imperiale, Ewa K Krasnowska, Thomas Lundeberg, Italo Nofroni, Maria Grazia Piccioni, … I prezzi indicati sono quelli per pazienti senza assicurazione sanitaria, Informazioni su servizi e prezzi non disponibili. +2 Altro. Framarino dei Malatesta, Marialuisa and Piccioni, Maria Grazia and Gentile, Tiziana and Lauri, Michela and Benedetti Panici, Pierluigi (2007) Transabdominal intralesional injection of Methotrexate in two angular live ectopic pregnancies. Four studies evaluated sample data and percentages for uVIN and dVIN (11, 13–14–15); the other 4 also considered immunostaining in normal epithelium, benign lesions, VIN and VSCC, without distinguishing between uVIN and dVIN (8, 16–17–18). Keratinization in basaloid carcinomas may sometimes complicate the differential diagnosis with poorly differentiated keratinizing VSCC; in particular, it can be arduous to discriminate dVIN from a benign vulvar lesion or from uVIN (21). p53 nuclear immunostaining was always negative in HPV-related disease. The baseline characteristics of the studies were extracted from each article: the first author, journal and year of publication, and the number of specimens examined in relation to the number of patients. Risulta sempre disponibile e, in caso di necessità, rintracciabile. Cucinotta was born in Messina, Province of Messina, Sicily, Italy. Please read and accept the terms and conditions and check the box to generate a sharing link. Ho preso visione della nota informativa. The last items were the outcomes explaining HPV-detection prevalence in association with the immunoreactivity used and the microscopic assessment cutoffs identified for each study to determine the positivity or negativity of the specimens. Sharing links are not available for this article. Maria Grazia ha indicato 3 esperienze lavorative sul suo profilo. dVIN was always HPV and p16INK4a negative, while p53 immunostaining was detected in 84%-90.8% of cases and MIB1 immunostaining was low in 96% of cases. 415.8k Followers, 630 Following, 2,304 Posts - See Instagram photos and videos from MariaGraziaCucinotta Official (@maria_grazia_cucinotta) For more information please contact us. Reuschenbach et al (18) also evaluated VSCC based on HPV DNA, p16INK4a and p53 expression, with tumor location limited to the anterior vulvar fourchette. La consiglio caldamente a tutti! Maria Grazia Cucinotta. Contact us if you experience any difficulty logging in. IARC. The sensitivity and specificity of p16INK4a to detect HPV-associated carcinomas were 100% and 98.7%, respectively, which compares favorably to histological criteria (with 93.8% sensitivity and 35.5% specificity) and to p53 negativity (with 62.5% sensitivity and 93.4% specificity). Maria Grazia Cucinotta (Messina, 27. jul 1968) je italijanska glumica. The initial findings of the patients and specimens surveyed were also specified. The sensitivity and specificity of p16INK4a immunostaining for detecting uVIN are close to 100%, higher than HPV DNA testing (HC2/PCR) and histological classification (11, 12). Ricevimento; Ultime pubblicazioni IRIS; martedì ore 10-11. Home » Intervista alla Dott.ssa Maria Grazia Piccioni – Parto Naturale, Cesareo, Indotto Vulvar disease is a rare affection of the lower genitalia, with incidence rates of 0.5-2.5 in 100,000 women (4% of gynecological malignancies) (1). Responsive Design. A difference in patient age was highlighted: in women with uVIN with adjacent SCC areas the median age was lower (52 years, standard deviation [SD] 13.4 years) than in those with dVIN with associated SCC (74 years, SD 12.5 years). +39 0323 32149 Cell. Watch Queue Queue Guarda il profilo completo su LinkedIn e scopri i collegamenti di Maria Grazia e le offerte di lavoro presso aziende simili. Join Facebook to connect with Mariagrazia Piccioni and others you may know. This is in agreement with the findings of Rufforny et al (16), who demonstrated that HPV-related VIN is a “younger” pathology than HPV-negative vulvar tumors. Vi presentiamo la nostra nuova testimonial d'eccellenza. PICCIONI Categoria: Animali; Pubblicato: Giovedì, 14 Novembre 2013 00:00 Scritto da Maria Grazia Sereni Stampa; Email; È in corso un’inchiesta sulle gare di volo dei piccioni in Belgio. Department of Obstetrics and Gynecology, “Sapienza” University of Rome, Rome, Italy See all articles by this author. Two studies applied p16INK4a and p53 immunostaining and 3 also applied Ki67 immunostaining. Invece la Dott.ssa e' la luce per tutte noi. Management of HPV-Related Cervical Disease: Role of p16INK4a Immunochemistry. HPV DNA positivity also was distinguishable between uVIN and dVIN: the first type showed a significantly higher percentage (84%) of hrHPV positivity (also if adjacent SCC areas were present), while 100% of dVIN cases were hrHPV negative. We included all English-language retrospective and prospective studies at primary diagnosis assessing p16INK4a immunostaining or p16INK4a/p53 staining, with HPV DNA testing (HC2/PCR) as the comparator test, on histological specimens of VIN and VSCC verified with a reference standard. Table I Details and findings of included studies. Our findings indicated that p16INK4a or p16INK4a/p53 immunoreactivity, along with histological diagnosis, could be a convenient means to adequately classify VIN and its connection to HPV infection. View the profiles of people named Grazia Piccioni. Maria Grazia Piccioni Department of Gynecological, Obstetrical and Urological Sciences, “Sapienza” University and Umberto I Polyclinic of Rome, Rome - Italy See all articles by this author. Attualmente sono Dirigente Medico di I Livello con la qualifica universitaria di Ricercatore Confermato e sono Responsabile di Progetti di Ricerca. The e-mail addresses that you supply to use this service will not be used for any other purpose without your consent. E' stata molto gentile ed umana e posso dire di essere stata visitata da una persona esperta e competenta. Maria Grazia ha indicato 1 #esperienza lavorativa sul suo profilo. Dott.ssa Maria Grazia Carrara, Faculty of Statistics Department of Statistical Sciences, Università degli Studi di Milan-Bicocca. Rufforny et al (16) in 2005 reported the different expression pattens of p16 for benign vulvar lesions, VIN1, VIN2, VIN3 and VSCC, concluding that in benign cases and in condylomatous lesions, p16INK4a and HPV DNA (generally the HPV16 genotype) showed no expression, thereby demonstrating the usefulness of p16INK4a in premalignant and malignant lesions. Some society journals require you to create a personal profile, then activate your society account, You are adding the following journals to your email alerts, Did you struggle to get access to this article? Viviamo nel periodo molto strano, la gente no ha fiducia, non ci sentiamo sicuri. Visualizza il profilo di Maria Grazia Barbieri su LinkedIn, la più grande comunità professionale al mondo. 1983 Rai Rete1 annuncio e sigla fine trasmissioni Maria Grazia Picchetti - Duration: 6:24. They concluded that this location is more frequent in younger women (56.7 years vs. 63.1 for other vulvar sites), but the expression of these markers did not vary from one site to the other. In the retrospective study by Riethdorf et al (15), p16INK4a was assessed by a monoclonal antibody to correlate its positivity levels to those of HPV DNA (PCR amplified) in vulvar cancers compared with benign conditions. View the profiles of people named Maria Grazia Piccini. Ho sempre ritenuto la ginecologia una materia importante e necessaria per il benessere della donna e per questa ragione, dopo la laurea in Medicina e Chirurgia, mi sono specializzata presso l'Università La Sapienza di Roma in Ginecologia ed Ostetricia. We found that nuclear and cytoplasmic immunostaining for p16INK4a was intense and diffuse in HPV-associated lesions and weak and focal in normal vulvar epithelium, nondysplastic lesions, lichen sclerosus and keratinizing vulvar squamous cell carcinoma. The electronic search yielded 36 eligible studies for the review. Visualizza i profili delle persone di nome Grazia Piccioni. Review studies indicated that p16INK4a or p16INK4a/p53 immunoreactivity along with histological diagnostics could adequately classify VIN and its connection to HPV infection. HPV, VIN, p16INK4a immunochemistry and p53 were used as keywords. pp. For Ki67 protein, immunoreactivity localization in the parabasal layers or in the lower third of the epithelium was considered “low-level”; Ki67 reactivity in the lower two-thirds or in the full-thickness epithelium was considered “high-level”. Vulvar squamous cell carcinoma is a multifactorial disease following two separate and independent pathways, p16INK4a immunohistochemistry improves interobserver agreement in the diagnosis of cervical intraepithelial neoplasia, p16 overexpression identifies HPV-positive vulvar squamous cell carcinomas, Management of HPV-related cervical disease: role of p16INK4a immunochemistry, A panel of p16(INK4A), MIB1 and p53 proteins can distinguish between the 2 pathways leading to vulvar squamous cell carcinoma, p16INK4A expression as biomarker for HPV 16-related vulvar neoplasias, Human papillomavirus infection and p16(INK4a) protein expression in vulvar intraepithelial neoplasia and invasive squamous cell carcinoma, Biomarkers p16, human papillomavirus and p53 predict recurrence and survival in early stage squamous cell carcinoma of the vulva, Medical and surgical interventions for the treatment of usual-type vulval intraepithelial neoplasia, Imiquimod 5% cream versus cold knife excision for treatment of VIN 2/3: a five-year follow-up, Vulvar intraepithelial neoplasia with superficially invasive carcinoma of the vulva, Surgical management and prognostic factors of vulvovaginal melanoma, Prognostic role of inguinal lymphadenectomy in vulvar squamous carcinoma: younger and older patients should be equally treated, Modified gluteal fold advancement V-Y flap for vulvar reconstruction after surgery for vulvar malignancies, Prognostic importance of human papillomavirus (HPV) and p16 positivity in squamous cell carcinoma of the vulva treated with radiotherapy, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy, HPV-related Vulvar Diseases and Perspectives of p16, http://www.iarc.fr/en/publications/pdfs-online/epi/sp160/CI5vol9.pdf, http://www.cancerresearchuk.org/about-cancer/type/vulval-cancer/about/risks-and-causes-of-vulval-cancer, http://seer.cancer.gov/statfacts/html/vulva.html.